Figure 2
Ribbon diagram and BH3 binding surface of Bcl-B. (a) Ribbon diagram of the Bcl-B:Bim complex. Bcl-B helices are labeled α1–α8, the N terminus labeled N and C terminus labeled C. The Bim-BH3 helix (yellow) with N-terminus labeled N′ and C-terminus labeled C′ is bound in a groove formed by helices α2–α5 and α8 of Bcl-B. Helices are colored as indicated in Figure 1. (b) Binding site and interactions of Bcl-B. Surface residues on Bcl-B within 4 Å of an atom on Bim are colored (yellow hydrophobic, red acidic, blue basic and cyan other) and residues on Bim in close contact (≤4 Å) with Bcl-B are shown as sticks and labeled with their residue type and sequence position. The molecular orientation is identical to the ribbon in A
