Figure 6 | Cell Death & Disease

Figure 6

From: The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist

Figure 6

Peptides spanning the Bax- and Bik-BH3 motifs displace Bim-BH3 from Bcl-B:Bim. Competition assay SPR sensorgrams demonstrate that peptides spanning the BH3 regions of Bax and Bik can displace Bim from the Bcl-B:Bim complex under increasing concentrations of BH3 peptide. Relative responses of samples between 1.25 and 40 μM BH3 peptides are shown. (a) Bax-BH3; (b) Bik-BH3. Other BH3 peptides had no effect

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