Figure 7

Summary of Bcl-2-regulated apoptotic pathways. (a) Bcl-B, Bcl-w and Bcl-2 selectively inhibit Bax-initiated apoptosis and A1 Bak-initiated apoptosis. Bcl-x_L and Mcl-1 inhibit both Bax- and Bax-initiated apoptosis. (b) Bim binds all prosurvival proteins, whereas other BH3-only proteins are more selective. Bcl-B binds only Bim and Bik tightly. Prosurvival proteins are displayed in unfilled boxes, BH3-only proteins in gray boxes and proapoptotic multi-BH proteins in black boxes. Interactions are indicated where binding data suggest a K_D<100 nM^{58, 60}