Figure 1 | Cell Death & Disease

Figure 1

From: Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer

Figure 1

BAXBAK silenced NSCLC cells have mitochondrial apoptosis block. (a) Western blot showing BAX and BAK protein expression in H460 and H1299 sh-BAXBAK clones compared with corresponding sh-NTNT controls. (b) Western blot for caspase-9 following 24 h treatment with indicated doses of staurosporine in sh-NTNT and sh-BAXBAK clones from H460 and H1299 cells. (c) Luminescent DEVD-ase assay measuring caspase-3-like activity in sh-NTNT and sh-BAXBAK cells from H460 and H1299 shown relative to untreated control. Data are expressed as mean±S.D. (*P<0.001)

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