Figure 5
From: Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer
Cisplatin-induced caspase-8 cleavage is acid sphingomyelinase (ASM)-dependent. (a) Western blot for caspase-8 after 2 h treatment with imipramine (50 μM) and 24 h cotreatment with cisplatin (5 μM) in H460 sh-BAXBAK cells. (b) Western blot for caspase-8 and ASM. (c) Western blot for caspase-8 from MOR and H1975 treated as in (a) showing imipramine attenuates cisplatin-induced caspase-8 cleavage in these NSCLC cell lines
