Figure 2 | Cell Death & Disease

Figure 2

From: Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD, and wild-type mice

Figure 2

PIO effects on memory performance analyzed with the ORT. Bar graphs depict ORT results as DI scores evaluated 24 h after the familiarization trial. Compared with WT, PS1-KI females developed memory deficits (CTRL-diet female PS1-KI versus CTRL-diet female WT, P=0.005). PIO-treated PS1-KI females exhibited improvements in recognition of displaced objects as indicated by increased DI scores (PIO-diet female PS1-KI versus CTRL-diet female PS1-KI, P=0.049). WT male mice treated with PIO showed a trend toward worsening of long-term memory (PIO-diet male WT versus CTRL-diet male WT, P=0.072). Females and males are depicted with white and gray bars, respectively; CTRL-diet is shown with opened bars, PIO-diet is represented with crossed bars. Data are shown as means±S.E.M.; n=12 for each group. Statistical analysis was performed with analysis of variance for repeated measures; *0.05<P≤0.095; **0.05≤P<0.01; ***P≤0.01

Back to article page