Table 1 LD50 of different therapies in parental and vorinostat-resistant U937 cells (μM)

From: Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance

Drug

U937 LD 50

U937-B8 LD 50

U937-B8 (1 week) LD 50

U937-B8 (3 weeks) LD 50

Vorinostat

1.1

9.8

4.7

4.9

Chloroquine

58.1

13.0

42.3

45.5

Taxol

0.0027

0.0025

0.0023

0.0022

Cisplatin

4.4

7.4

12.1

11.0

Arsenic trioxide

4.5

11.0

11.0

9.6

Doxorubicin

0.074

0.153

0.179

0.165

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