Figure 3 | Cell Death & Disease

Figure 3

From: Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest

Figure 3

Increased RT and CT resistance in NSCLC TICs. The clonogenic capacity of H125 and A549 TICs and bulk cells irradiated with 2, 4 or 8 Gy was assessed. (a) Scanned plates from a representative experiment. (b) The colony number relative to untreated cells (average±S.D. of three independent experiments). (c) Cell viability of H125 and A549 bulk cells and TICs after 72 h of continuous cisplatin exposure was measured using MTT assay. *P<0.05; **P<0.01; ***P<0.001

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