Table 3 Sensitivity of UKF-NB-3 cells, UKF-NB-3rNutlin10 μM cells, UKF-NB-3rNutlin10 μM cells transduced with a lentiviral vector encoding wild-type p53 (UKF-NB-3rNutlin10 μMwtp53), and UKF-NB-3rNutlin10 μM cells transduced with a control vector (UKF-NB-3rNutlin10 μMcontrol) to RITA or nutlin-3 indicated by the concentration that reduces cell viability by 50% (IC50) indicated by MTT assay after a 5 day treatment period
Cell line | RITA ( μ M) | Nutlin-3 ( μ M) |
---|---|---|
UKF-NB-3 | 0.11±0.02 | 1.47±0.15 |
UKF-NB-3rNutlin10 μM | 0.62±0.04 | 32.83±2.91 |
UKF-NB-3rNutlin10 μMwtp53 | 0.24±0.03 | 5.02±1.73 |
UKF-NB-3rNutlin10 μMcontrol | 0.58±0.03 | 36.19±3.08 |