Table 4 Numbers of genes differentially expressed relative to UKF-NB-3 (false discovery rate (FDR)<0.05 or <0.01 after correction for multiple testing) in RITA- or nutlin-3-adapted UKF-NB-3 sub-lines as determined by microarray measurement of mRNA abundance

From: Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents

Comparison UKF-NB-3 versus

Differentially expressed genes (FDR<0.05)

Differentially expressed genes (FDR<0.01)

All sub-lines

1360

520

All RITA-resistant sub-lines

1495

676

All nutlin-3-resistant sub-lines

6465

4090

UKF-NB-3rRITA10 μMII

1985

374

UKF-NB-3rRITA10 μMIII

2465

337

UKF-NB-3rRITA10 μMIV

3606

817

UKF-NB-3rNutlin10 μMII

2528

75

UKF-NB-3rNutlin10 μMV

6575

2842

UKF-NB-3rNutlin10 μMVI

4831

1148

UKF-NB-3rNutlin10 μMVIII

5830

2004