Figure 6
From: Intrinsic regulation of hemangioma involution by platelet-derived growth factor
PDGF-BB, but no other PDGF polypeptides, prevent full functional differentiation of hemSCs. (a) Oil red O staining of hemSCs cultured in low (10 ng/ml) and high (50 ng/ml) PDGF polypeptide levels. PDGF-AA and –AB were ineffective against preventing adipogenic differentiation at 10 and 50 ng/ml. (b) Quantitative analysis of early adipogenesis-specific transcription factors (C/EBPα and PPARγ) and late marker of adipocytes, FABP-4 (*P<0.05 compared to adipogenic media; n=3). (c) Expression of FABP-4 in hemSCs treated with 50 ng/ml PDGF-AA. (d) Inhibition of adipogenesis by PDGF-BB in bm-MPCs (data presented relative to adipogenic media; *P<0.05 compared with adipogenic media; n=3)
