Figure 7
From: Intrinsic regulation of hemangioma involution by platelet-derived growth factor
Inhibiting cell-autogenous PDGF signaling enhances adipogenesis. (a) Oil red O staining of hemSCs exposed to adipogenic media with or without PDGFR inhibitors, AG-370 and AG-1296, and PDGFR neutralizing antibodies. (b) Quantitative analysis of C/EBPα and PPARγ in cells exposed to PDGF inhibitors as in (a) (data presented relative to control media; *P<0.05 compared with control media; †P<0.05 compared with adipogenic media; n=3). (c) Effect of PDGFR-α and PDGFR-β-neutralizing antibodies and chemical inhibitors on reversing the inhibition by exogenous PDGF-BB (*P<0.05 compared with PDGF-BB treatment)
