Figure 1 | Cell Death & Disease

Figure 1

From: Endothelial cells regulate p53-dependent apoptosis of neural progenitors after irradiation

Figure 1

The apoptotic response of subgranular cells in the SGZ of the dentate gyrus after irradiation is radiation dose- and smpd1 genotype-dependent. Cells in the SGZ of the dentate gyrus of smpd1+/+ (a–c), smpd1+/– (d–f) and smpd1−/− (g–i) mice undergo radiation dose-dependent apoptosis at 8 h after irradiation. Apoptotic cells (arrows) are identified by their characteristic nuclear condensation and fragmentation using DAPI nuclear staining. The number of apoptotic cells estimated by stereology is radiation dose (P<0.0001, two-way ANOVA; n=minimum of 3 per dose group) and smpd1 genotype- dependent (P<0.0001). (j) Data represent means±S.E.M

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