Figure 7
Whole animal respiration is reduced in HtrA2-deficient mice. Respiratory rate (fR) and tidal volume (VT) were assessed by whole-body plethysmography in conscious WT, heterozygous and HtrA2-KO mice aged P20. (a–c) Respiratory rate (a) was reduced in HtrA2-KO mice compared with their WT and heterozygous counterparts, but tidal volume (b) was unchanged. Minute ventilation (VE), calculated as the product of fR and VT, was therefore significantly reduced in HtrA2-KO animals (c). Data are represented as mean±S.E.M., * indicates P<0.05
