Figure 1
NFV and BZ synergistically inhibit proliferation of NSCLC and MM cells. (a) Growth inhibition by NFV (▪), BZ (▴), or the combination (●). NSCLC and MM cells were treated with drugs at the indicated concentrations for 48 and 72 h, respectively. Bars, S.D. (b) Cells were prepared and treated as described in (a). Computer-simulated Fa-CI curves display synergism (CI<1), additive effect (CI=1), or antagonism (CI>1) for the entire spectrum of effect levels in the combination (see also Supplementary Table 1A, right). × Indicates the actual Fa-CI plot based on experimental values (see also Supplementary Table 1A, left). (c) Growth inhibition of BZ-resistant MM cell lines. RPMI8226 V10R and Kas-6 V10R cells were treated with either 8 μM NFV, BZ at the indicated concentrations, or the combination for 72 h, respectively. Bars, S.D. (d) Cells were prepared and treated as described in (c). × Indicates the actual Fa-CI plot based on experimental values (see also Supplementary Table 1B)
