Figure 3 | Cell Death & Disease

Figure 3

From: Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells

Figure 3

Combining NFV with BZ enhances cytosolic proteotoxicity. (a) Enhancement of Ub-proteins. H157 cells were treated with either DMSO, 10 μM NFV, 12.5 nM BZ, or the combination for 48 h, and RPMI8226 cells were treated with either DMSO, 10 μM NFV, 6.25 nM BZ, or the combination for 48 h. Immunoblotting was performed. (b) Increase of HSP70 indicates the existence of proteotoxic stress in the cytosol. Cells were treated with the drugs at the concentration as described in (a) for the indicated time. Level of HSP70 was assessed by immunoblotting

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