Figure 7 | Cell Death & Disease

Figure 7

From: Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells

Figure 7

Proteototoxic mechanisms of the combination of NFV and BZ. Both NFV and BZ can induce ER stress, whereas the combination further enhances ATF3 and CHOP to result in cell death. In addition, NFV-induced ER stress triggers ERAD to accumulate Ub-proteins, which are typically degraded by UPS. As BZ inhibits UPS, the combination of NFV and BZ enhances the accumulation of Ub-proteins through ERAD without degradation by UPS, resulting in cytosolic proteotoxicity

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