Figure 1 | Cell Death & Disease

Figure 1

From: Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro

Figure 1

Erythroid proliferation is decreased to greater extent in DBA patients carrying mutations in RPL11 gene, compared with patients with mutations in RPS19 gene. (a) Representative immunoblots of erythroid precursors with RPS19 and RPL11 antibodies from DBA patients mutated in RPS19 (left panel) and in RPL11 (right panel) during terminal erythroid differentiation compared with controls. The expression levels were normalized with expression levels of actin. (b) Mean erythroid progenitor and precursor cell proliferation from peripheral CD34+ cells from controls (n=15), DBA patients carrying mutations in RPS19 (n=12) or in RPL11 (n=3) gene from D0 to D12 during erythroid differentiation. Statistical test: Student’s t-test

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