Figure 5
From: FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential
FKBP51 stains mouse metastasis. (a) FKBP51/nestin double-stain of melanoma cells in a lung and liver biopsy (IHC, × 200), from untreated mouse. (b) Expression levels of FKBP51 in mouse organs. RNA was extracted from a mix of multiple samples of tissue collected from the perihilar, apical, and basal areas of both lungs and from hilum and left and right lobes of livers. Graphic representation of normalized expression rates (mean and S.D.) of FKBP51 mRNA in lungs and livers excised from mice. A sample from FKBP51 siRNA-treated mouse was arbitrarily used as reference sample (expression=1). Expression of FKBP51 was significantly reduced in organs of mice receiving FKBP51 siRNA
