Figure 2 | Cell Death & Disease

Figure 2

From: A DR6/p75NTR complex is responsible for β-amyloid-induced cortical neuron death

Figure 2

DR6 and p75NTR form a receptor complex. (a) AP-DR6 binding to HEK 293 cells expressing p75NTR and not to untransfected control cells. The non-homogenous staining pattern reflects incomplete transfection. Scale bar=25 μm. (b) Quantitative assessment of a by ELISA. (c) DR6/p75NTR co-immunoprecipitation in HEK 293 cells overexpressing Myc-tagged DR6 and p75NTR. (d) DR6/p75NTR co-immunoprecipitation in fetal human spinal cord lysates. (e) Immunocytochemical staining to co-localized the DR6 and p75NTR expression in cultured neurons. Scale bar=25 μm. (f) Competition ELISA showing the binding of europium-labeled human p75NTR to human DR6 ectodomain-coated plates in the presence and absence of blocker constructs

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