Figure 8 | Cell Death & Disease

Figure 8

From: Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

Figure 8

Oroxylin A-induced SIRT3-mediated cyclophilin D deacetylation, triggered HK II detachment, and inhibited glycolysis. Oroxylin A caused an increase in the expression and activity of SIRT3. In turn, SIRT3 promoted deacetylation of cyclophilin D (Cyp-D), resulting the dissociation of Cyp-D from ANT-1, and promoting the detachment of HK II from the mitochondria VDAC. As a result, the glycolysis was inhibited by Oroxylin A

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