Figure 2 | Cell Death & Disease

Figure 2

From: Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

Figure 2

Aβ oligomers differentially affect the expression of mGluR5 and InsP3R1 in astrocytes from different regions of the brain. (a) Representative immunostaining of mGluR5 and InsP3R1 (green) and DAPI-staining for nuclei (blue) in astrocytes cultured from EC and hippocampus of non-Tg mice at 7 days in vitro. (b) Quantifications of the expression (western blot analysis) of mGluR5 and InsP3R1 expression in control cells and cells treated with 100 nM of Aβ for 72 h in hippocampal cultures (upper graph) and EC cultures (lower graph) (*P<0.05, averages of seven cultures for non-Tg mice and four cultures for 3xTg-AD mice)

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