Figure 3 | Cell Death & Disease

Figure 3

From: Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

Figure 3

Effect of Aβ treatment on metabotropic glutamatergic Ca2+ signalling in EC and hippocampal astrocytes from non-Tg and 3xTg-AD mice. (a and b) Representative traces of DHPG-induced Ca2+ responses in hippocampus and EC in control and in Aβ-treated cells derived from non-Tg mice, and control and Aβ-treated cells derived from 3xTg-AD mice (n=30 cells for each experimental protocol). The cells were exposed to 100 nM of Aβ for 72 h and then loaded with Fluo4-AM, and stimulated with 100 μM DHPG for 15 s. (c) Mean values for integrals of [Ca2+]i transients induced by DHPG stimulation (n=150 cells from five different cultures for each experimental protocol)

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