Figure 5
Effect of cannabinoids on Krebs cycle. Panc1 were treated for 12 h with 200 μM (a) GW or (b) ACPA and the metabolites analysis was performed as reported in Materials and Methods.KET, alpha-ketoglutarate; MA, malate; SUCC, succinate. (c) NADH was measured after 12 h treatment with 200 μM GW or ACPA in the presence or absence of a pre-treatment for 1 h with 20 mM NAC, as reported in Materials and Methods. Values are the means of three independent experiments (±S.D.). Statistical analysis: *P<0.05, **P<0.01, and ***P<0.001
