Figure 1 | Cell Death & Disease

Figure 1

From: Loss of connective tissue growth factor as an unfavorable prognosis factor activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma

Figure 1

Reduced expression of CTGF was correlated with poor prognosis in NPC. (a) Using qPCR examination, CTGF mRNA expression was markedly decreased in 62 NPC tissues compared with 20 nasopharynx tissues (P=0.0036). (b) CTGF protein expression was progressively decreased in 37 atypical hyperplasia and 213 NPC samples compared with 49 normal nasopharynx tissues and 21 squamous epithelium by immunohistochemistry assay. (1) CTGF expression in normal epithelium, 1–2: strong expression; (2) CTGF expression in squamous epithelium, 3: strong expression; (3) CTGF expression in atypical hyperplasia tissue, 4: weak expression; (4) CTGF expression in NPC, 5: strong expression; 6: weak expression; 7: negative expression. (c) Lower expression levels of CTGF reduced the overall survival time of 173 NPC patients with clinical prognosis information.

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