Figure 6 | Cell Death & Disease

Figure 6

From: Loss of connective tissue growth factor as an unfavorable prognosis factor activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma

Figure 6

High expression of miR-18b promotes cell proliferation and is negatively correlated with the expression of CTGF in NPC. The ability of cell proliferation was markedly elevated after increasing miR-18b mimics expression in NPC. (b) Transduction of miR-18b inhibitor suppressed cell growth in NPC cells. (c) miR-18b expression was dramatically elevated in NPC tissues and NPC cells compared with nasopharynx tissues. (d) miR-18b was negatively correlated with the expression of CTGF in NPC samples. (e) CTGF protein expression was suppressed in xenograft tumor specimens after stably knocking down CTGF expression. (f) Reduced CTGF expression induced the miR-18b expression in xenograft tumor specimens. Data are presented as mean±S.D. for three independent experiments (*P<0.05)

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