Figure 1 | Cell Death & Disease

Figure 1

From: The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer

Figure 1

Cabozantinib eliminates PDA cells but is less toxic to non-malignant ductal cells. (a) Cells were left untreated or were treated with 5, 7.5 or 10 μ M cabozantinib (XL184). Seventy-two hours later viability was detected by MTT-assay and apoptosis by staining with annexinV-FITC followed by FACS-analysis. (b) MIA-PaCa2 and Capan-1 cells were cultured in ultra-low attachment plates for spheroid formation. Three days later cells were treated as described above and as indicated. Ten days after treatment spheroids were evaluated morphologically by microscopy and the percentage of spheroids in each group were determined by counting viable spheroidal cells. The number of spheroids in the control was set to 100%. Representative pictures of MIA-PaCa2 spheroids are shown

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