Figure 4 | Cell Death & Disease

Figure 4

From: The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer

Figure 4

Long-term treatment with cabozantinib downregulates SOX2. (a) Proteins were isolated from parental BxPc-3 cells and the derived subclones XL-5 and XL-7. Binding of proteins to antibodies spotted in duplicate to the membrane of a Human Pluripotent Stem Cell Array was detected as described in Figure 3a. Reference spots are located at the coordinates A1, A4 and F1. Spot E4 is the PBS-negative control. (b) mRNA from parental BxPc-3 cells and derived subclones XL-1 to XL-7 were harvested and expression of SOX2 was examined by qRT-PCR. (c) Likewise, protein expression of SOX2 was examined by western blot analysis

Back to article page