Figure 1 | Cell Death & Disease

Figure 1

From: Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program

Figure 1

(a) Western blot indicating positive expression of hERG1 channel in SKBr3 cells. (b) Effect of NS1643 (50 μ M) on hERG1 current detected in SKBr3 cells 48 h after drug treatment compared with untreated cells (control). hERG1 current specificity was confirmed by application of the selective hERG1 blocker E4031 (5 μ M). (c) Effect of NS1643 on SKBr3 cell proliferation rate at different time points (n=6; *P<0.01). (d) Western blot indicating negative expression of hERG1 channel in CHO cells. (e) Effect of NS1643 (50 μ M) or E4031 (5 μ M) on hERG1 current detected in CHO cells 48 h after drug treatment compared with untreated cells (control). (f) Effect of NS1643 on CHO cell proliferation rate at different time points compared with untreated cells (n=6). (g) Measurements of proliferation rates of SKBr3 during NS1643 treatment (50 μ M; square box) and after drug removal (triangle) compared with control (diamond). (n=6; *P<0.025)

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