Figure 7
From: Glycation exacerbates the neuronal toxicity of β-amyloid
Inhibition of Aβ-AGE formation suppresses RAGE upregulation and GSK-3β activation in Tg2576 mice. Tg2576 (Tg) or wild-type (WT) mice at 6-month old were injected subcutaneously with AG or NS for 3 months. At 9 month old, the mice were killed and levels of RAGE and the phosphorylated GSK-3β at Ser9 were estimated by western blot. RAGE and pS9-GSK-3β were normalized, respectively, to DM1A and total GSK-3β. n=3.*P<0.01 versus WT+NS group. #P<0.01 versus Tg+NS group
