Figure 7
From: Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2
Schematic model of signaling pathways in salinomycin-induced cell growth inhibition and apoptosis. Salinomycin exerts its antitumor effects by inhibition of oncogenic proteins such as Stat3, cyclin D1, and Skp2 but upregulates the tumor suppressor p27Kip1. Salinomycin inhibits Stat3 activation and thus decreases transcription of its target proteins, including cyclin D1 and survivin, which are important for cell cycle progression and cell survival. Salinomycin activates the APC/Cdh1–Skp2–p27Kip1 pathway, leading to degradation of Skp2 and thus accumulation of the cell cycle inhibitor p27Kip1, which culminates in cell cycle arrest. Salinomycin also activates apoptosis signaling pathways including Akt inactivation and caspase-3 activation, which leads to cell death
