Figure 6 | Cell Death & Disease

Figure 6

From: Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing

Figure 6

Melanoma spheroids integrated into skin equivalents respond to TRAIL+cisplatin but not to TRAIL+UVB. Organotypic skin equivalents containing 451-LU spheroids were left (a) untreated or subjected to short-term treatment with (b) TRAIL (500 ng/ml), (c) UVB (400 J/m2) or (e) cisplatin (40 μM) alone or in (d) TRAIL+UVB and (f) TRAIL+cispatin combination, respectively, applied twice on days 13 and 15. On day 17, paraffin sections were stained for Ki67, cleaved caspase-3 and TUNEL positivity, respectively. One representative out of three independently performed experiments is shown

Back to article page