Figure 1 | Cell Death & Disease

Figure 1

From: KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a

Figure 1

KPNA2 is overexpressed in EOC cells and tissue samples; and KPNA2 upregulation is associated with poor prognosis. (a) Gene expression microarray analysis showing that KPNA2 was upregulated (10-fold) compared with HOSE samples. (b) Real-time qRT-PCR analysis showing the average expression levels of KPNA2 in EOC (n=191) and HOSE (n=10) tissue samples. Expression levels are normalized to β-actin mRNA. Error bars represent S.E. (c) Western blot analysis of KPNA2 protein expression in two HOSE samples and seven EOC cell lines; β-actin was used as a loading control. (d) KPNA2 protein expression in two HOSE samples and seven EOC cell lines was quantitated using ImageJ software (Wayne Rashband). (e) Kaplan–Meier analysis showing that the expression of KPNA2 was significantly associated with poor overall survival in 191 EOC cases (P=0.012, log-rank test). (f) Kaplan–Meier analysis showing that expression of KPNA2 was significantly associated with poor relapse-free survival in 191 EOC cases (P<0.001, log-rank test)

Back to article page