Figure 1

(a) Cytotoxicity of vorinostat was assessed in the wild-type SK-N-Be(2)C and SK-N-SH cell lines using the MTT cell proliferation assay. SK-N-Be(2)C (b) and SK-N-SH (c) cells were treated with doxorubicin at 10−6 M and 5 × 10−6 M for 96 h after which cell survival was assessed using MTT. Error bar=95% confidence intervals. *P<0.0001. Experiments were repeated at least three times