Figure 3 | Cell Death & Disease

Figure 3

From: Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice

Figure 3

Obatoclax and SaliPhe but not gemcitabine inhibit the ABT-263-mediated death of IAV-infected RPE cells. (a) RPE cells were treated with ABT-263 (0.4 μM) and with increasing concentrations of obatoclax, SaliPhe or gemcitabine. Cells were mock- or IAV-infected (WSN, moi 10), and cell viability was measured using a CTG assay 24 h after infection. (b) RPE cells were treated with obatoclax (1 μM), SaliPhe (1 μM) or gemcitabine (10 μM) and with increasing concentrations of ABT-263. Cells were mock- or IAV-infected (WSN, moi 10), and cell viability was measured using a CTG assay 24 h after infection. (c) RPE cells were IAV-infected (WSN, moi 10) and treated with ABT-263 (0.4 μM) every hour. Cell viability was measured using a CTG assay 24 h after infection. (d) Schematic representation showing the stage of IAV replication cycle at which ABT-263 triggers cell death. All error bars, s.d. (n=3)

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