Figure 5 | Cell Death & Disease

Figure 5

From: Differentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that control cell death

Figure 5

P2X7 ion currents in dASCs. (a) Representative recordings of ion currents measured from dASC in response to application of increasing concentrations of ATP (upper traces) and BzATP (lower traces); agonists were applied for 30 s with 60-s intervals. (b) The concentration dependence of peak amplitude of ion currents recorded as in (a); n=6–10 for ATP and 5–10 for BzATP. (c and d) Inhibition of ATP-induced ion currents by P2X7 antagonist AZ 10606120; ATP was applied at 3 mM for 30 s; AZ 10606120 at 300 nM was added to the bath 1–2 min before ATP challenge and remained in the presence of ATP; the average values for peak amplitudes in control and in the presence of the antagonist are shown in (d). Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison test, n=7, *P<0.05

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