Figure 1

Rad54 KO ovaries have reduced ovarian reserve. (a) Hematoxylin and eosine staining of 3-month-old WT and KO ovaries. Lower panel represents an enlarged picture ( × 40 objective) showing primordial follicles (*) (b) Follicle counts show depletion in ‘pri-antral’ follicles (represents the sum of primary, secondary, pre-antral and antral follicles) and particularly the primordial follicle pool that determines the female fertility life span (n=5)