Figure 4 | Cell Death & Disease

Figure 4

From: Rad54 is required for the normal development of male and female germ cells and contributes to the maintainance of their genome integrity after genotoxic stress

Figure 4

Both KO female and male E13.5 embryonic gonads are more radiosensitive than WT. (a) Immunohistochemical staining of DDX4 (purple) (left panels) or double staining of DDX4 (purple)/POU5F1 (brown) (right panels) of E14.5 gonad cross sections from mice irradiated 24 h before at 0.5 Gy. (b) Representation of premeiotic germ cell counts in the whole gonads. In testes, DDX4-positive cells were counted. In ovary, POU5F1 and DDX4-double positive cells (i.e., oogonia) were counted. Four to six animals per group were analyzed. Data are presented as the percentage of the corresponding non-irradiated control (mean±S.E.M.). Statistically significant differences between irradiated and non-irradiated gonads are indicated by asterisks (*P<0.05; **P<0.01)

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