Table 1 Biomechanical measures of femur and vertebrae

From: Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone

   

OVx+

OVx+

OVx+

   
   

1

5

10

   
 

Sham + V

OVx+ V

mg/kg/day

OVx+ Ald

OVx+ Bzb

OVx+ PTH

Femoral bone strength

 Energy(mJ)

4.86±0.83***

1.5±0.25

4.04±0.67**

4.02±0.22**

4.86±0.50***

4.67±0.81***

3.87±0.15***

3.91±0.19***

 Stiffness (N/mm)

65.4±10.16**

15.64±2.33

6.75±12.21**

39.76±11.05**

55.54±1.45***†§

53.53±6.79***

50.73±5.79***

54.34±8.79***

Vertebral compressive strength

 Energy(mJ)

469±73.18**

195.3±31.5

361±9.61*

401.6±25.31*

477.3±8.17**‡¶

464.6±32.97**

448.3±18.58**

415.6±9.83*

 Stiffness(N/mm)

289.66±7.53*

163.66±27.09

226.66±28.52

230.667±14.19*

314.33±8.83*†¶

279±8.38*

292.33±4.66*

297±7.88*

  1. Abbreviations: Ald, alendronate; Bzb, bortezomib; OVx, ovariectomy; PTH, parathyroid hormone.
  2. Each parameter represents pooled data from 10 mice/group and values are expressed as mean±S.E. *P<0.01, **P<0.01 and ***P<0.001 compared with OVx+V group. Inter-groups comparison shows †P<0.01 when 10 mg/kg/day dose compared with 1 mg/kg/day dose; ‡P<0.05 when 10 mg/kg/day dose compared with 1 mg/kg/day dose; §p<0.01 when 10 mg/kg/day dose compared with 5 mg/kg/day dose; P<0.05 when 10 mg/kg/day dose compared with 5 mg/kg/day dose
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