Figure 7
Neuroprotective effects on neuronal injury induced by I/R in hippocampal CA1 region targeting at GluR6-FasL-Trx2-Procaspase-3 pathway. (a) Cresyl violet staining was performed on sections form hippocampus at 5 days reperfusion after 15 min ischemia. Pretreatment with NS102 (10 mM), Fasl-AS, TrxR2-AS (10 nmol AS was given to the rats every 24 h for 3 days), or auranofin (10 mM) almost reversed the neuronal death in CA1 area (n=6; *P<0.05 compared with sham group, #P<0.05 compared with I/R 5d group). (b) TUNEL staining was performed on sections form hippocampus at 3 days reperfusion after 15 min ischemia. Hippocampal samples counterstained with methyl green were shown. Pretreatment with NS102 (10 mM), Fasl-AS, TrxR2-AS (10 nmol AS was given to the rats every 24 h for 3 days), or auranofin (10 mM) almost reversed the neuronal apoptosis in CA1 area (n=6; *P<0.05 compared with sham group, #P<0.05 compared with I/R 3d group). Scale bars, left column, 200 μm (magnification × 40); right column, 10 μm (magnification × 400). Data are represented as means±S.D.
