Table 1 IAPs and negative prognosis

From: IAPs on the move: role of inhibitors of apoptosis proteins in cell migration

Cancer type

IAPs involved

Detection parameter

References

IAPs and negative prognosis

 Esophageal squamous cell carcinoma

cIAP1 and cIAP2

Genomic DNA and RNA (11q21–23 amplicon)

Imoto et al.119

 SCLC and NSCLC

cIAP1 and cIAP2

Genomic DNA and Protein (11q21–23 amplicon)

Dai et al.27

 Hepatocellular carcinoma

cIAP1

Genomic DNA and RNA (11q21–23 amplicon)

Zender et al.29

 MALT lymphoma

cIAP2

RNA (t(11 : 18)(q21 : 21) translocation)

Dierlamm et al.120

 Acute myeloid leukemia (ALL)

cIAP2

RNA

Hess et al.33

 Bladder cancer

XIAP

Protein and RNA

Li et al.36

 

Nuclear cIAP1

Protein

Che et al.38

 Colorectal cancer

XIAP

RNA and protein

Xiang et al.37

 

cIAP2

Protein

Krajewska et al.35

 Breast cancer

Nuclear XIAP

Protein

Zhang et al.39

 Cervical sqamous cell carcinoma

Nuclear cIAP1

Protein (resistance to radiotherapy)

Imoto et al.40

  1. Various IAPs reported to be upregulated in cancers and/or linked to negative tumor prognosis are listed