Figure 6 | Cell Death & Disease

Figure 6

From: Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway

Figure 6

The in vivo efficacy of NA in an NPC nude mouse model. (a) C666-1 cells were subcutaneously injected into the right flank of mice and tumor volumes in the control group and NA-treated group were measured every day. On day 37 after transplantation, when the average tumor volumes of control tumors exceeded 1 cm3, the mice were killed. Data are shown as mean±S.D. of eight mice. (b) During the treatment period, the effect of NA on the average body weight of mice was measured every day. Data are shown as mean±S.D. of eight mice. (c) At the treatment end point, mice were killed and tumors were removed and photographed. (d) The tumor weight of mice from control group and NA-treated group was measured. Data are shown as mean+ S.D. of eight mice. (e) Immunohistochemical examinations of phosphorylated mTOR, Akt and the expression of HK2 in tumor sections from control mice and NA-treated mice. All panels are of the same magnification ( × 400)

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