Figure 3

(a) CDDP-induced auditory cell toxicity. (b) Dose-dependent effect of RXN on HEI-OC1 cells. (c) Dose-dependent effect of RXN on CDDP-induced toxicity in HEI-OC1 cells. (d) Effect of RXN on CDDP-induced apoptosis: RXN significantly decreased CDDP-induced apoptosis in the RXN+CDDP group compared with that in the CDDP-only group. *P<0.05, **P<0.01. Asterisk on the bar means compared with the normal control group. All experiments were performed in triplicate