Figure 2 | Cell Death & Disease

Figure 2

From: The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

Figure 2

MPT0E028 enhances EGFR inhibitor-induced cytotoxicity in erlotinib-resistant NSCLC cells. Erlotinib-resistant A549 (a), H1299 (b), H1975 (c), PC9/IR (d), and CL97 (e) cells were incubated with increasing concentrations of erlotinib (E) and MPT0E028 (M) alone or concurrently for 72 h. (f) MPT0E028 and erlotinib together synergistically suppress colony formation. Clonogenic survival was assessed as described in the Materials and Methods section, and cell viability was determined by MTT assay. The results are expressed as the percentage surviving cells in drug-treated cultures relative to DMSO-treated control cells. Error bars represent S.D. CI values for the combination of erlotinib and MPT0E028 were calculated using the Calcusyn software (Cambridge, UK), as described in the Materials and Methods section

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