Table 1 Molecular characteristics and cytotoxicity of MPT0E028 and erlotinib

From: The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

Cell line

Characters

E028 (IC50)

SAHA (IC50)

Erlotinib (IC50)

A549

K-Ras mut, EGFR wt

1.55±0.14

8.98±0.24

>20

H1299

EGFRwt, N-RAS (Q61K)

1.1±0.02

5.25±0.38

>20

NCI-H1975

EGFR mut T790M

1.3±0.13

5.34±0.15

>20

PC9/IR

EGFR exon 19 del, activating mut

1.66±0.41

5.32±0.44

>20

CL97

EGFR mut T790M, G719A

1.35±0.11

4.57±0.35

>20

  1. Abbreviations: Del, deletion; Mut, mutant; WT, wild-type.
  2. Cytotoxicity of erlotinib, MPT0E028 or SAHA, and the mutation status of the EGFR and K-Ras genes in human NSCLC cell lines are shown. The cytotoxicities of erlotinib, MPT0E028, or SAHA were determined by MTT assays after 72 h of drug treatment, and are expressed as the IC50 (μM). Each value represents the mean±standard deviation (S.D.) from at least three independent experiments.
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