Figure 4 | Cell Death & Disease

Figure 4

From: Lithium chloride attenuates cell death in oculopharyngeal muscular dystrophy by perturbing Wnt/β-catenin pathway

Figure 4

LiCl enhances muscle differentiation of C2C12 cells expressing GFP-expPABPN1-13Ala and 17Ala. LiCl increases the differentiation index of C2C12 cells expressing GFP-expPABPN1 (13Ala and 17Ala). The histogram represents the fusion index calculated at the indicated times after the addition of DM for cells expressing GFP-expPABPN1-13Ala and GFP-expPABPN1-17Ala treated or not treated with 2.5 mM LiCl. Myogenic index was determined as the ratio of the nuclei number of cells containing two or more nuclei to the total nuclei number of desmin C2C12-stained myotubes. The number of nuclei within each individual myotube was counted for 100–150 myotubes per well. At least three different fields containing 100 cells were counted. Data are the mean ±S.E. of three independent experiments

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