Figure 7 | Cell Death & Disease

Figure 7

From: Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110

Figure 7

Suppression of neural degeneration in GMR-HQ retinae by co-expression of DNAJB1 and APG-1. (a) The time course of degeneration as determined by optical neutralization. Each data point was based on examination of ≥100 ommatidia from ≥7 flies. Error bars represent the SDs. Asterisks indicated statistically significant differences (Student’s unpaired t-test; P<0.05) from GMR-HQ. (b–f) Examination of morphology by TEM. (b) Control, (c) GMR-HQ (GMR-HQ/+), (d) GMR-HQ/ninaE>dnaJB1 (GMR-HQ ninaE-Gal4/UAS-dnaJB1), (e) GMR-HQ/ninaE>apg-1(GMR-HQ ninaE-Gal4/UAS-apg-1), (f) GMR-HQ/ninaE>dnaJB1 apg-1 (GMR-HQ ninaE-Gal4/UAS-dnaJB1 UAS-apg-1). Flies were reared in a 12 h light/12 h dark cycle at 25 °C, and 7-day-old flies were used

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