Figure 4 | Cell Death & Disease

Figure 4

From: CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia

Figure 4

KN-93 exerts an antiarrhythmic effect on CPVT-iPSC-derived CMs. Representative traces of evoked (a) and spontaneous (b) APs from CPVT-iPSC in the presence of a β-adrenergic stimulus (1 μM Iso). DADs are indicated by arrows. (c) Coperfusion with 1 μM KN-93, a CaMKII inhibitor, prevented this arrhythmogenic effect in CPVT-iPSC-derived CMs (n=7, P<0.05)

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