Figure 5 | Cell Death & Disease

Figure 5

From: CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia

Figure 5

Calcium transient detection in iPSC-derived 3D-beating clusters. (a) Calcium transient activation time map and representative traces of WT cluster recorded in basal conditions (top), in the presence of a β-adrenergic stimulus (1 μM Iso) (middle) and in coperfusion with 1 μM KN-93 (bottom) (n=6). Dashed red lines indicate the zoomed-in regions of the calcium upstroke represented below. (b) Same as (a) for CPVT clusters (n=8). All traces are scaled to control value as normalized dF/F 10%. Rainbow line indicates the isochrones of calcium impulse initiation and propagation

Back to article page