Figure 1 | Cell Death & Disease

Figure 1

From: Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma

Figure 1

Reduced expression of PDCD4 promoted the progression and poor prognosis of NPC patients. (A) Decreased PDCD4 expression was shown in NPC by microarray data analysis of GSE2370 data set retrieved from the GEO database. (B) Compared with nasopharynx tissues, PDCD4 expression was markedly decreased in NPC tissues and NPC cells (P<0.001). (C) Compared with nasopharynx tissues, PDCD4 protein expression was significantly downregulated in NPC tissues. (D) PDCD4 expression was progressively decreased in NPC samples compared with normal nasopharynx tissues, squamous epithelium and atypical hyperplasia. (1) PDCD4 expression in normal epithelium, a–d: strong expression; (2) PDCD4 expression in squamous epithelium, e: strong expression; (3) PDCD4 expression in NPC, f–i: Strong and positive expression; j–m: weak expression and negative expression. (E) Lower levels of PDCD4 reduced the survival time of NPC patients

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